Chemistry exhibits many of the hallmarks of Taormino's last feature for Adam & Eve, House of Ass, in which several porn stars (including Chemistry performer Mr. Marcus) hole up for two days with "perv cams", have spontaneous sex, learn about life and each other, and unload in confessional segments.
Of House of Ass Taormino wrote, "See what happens when seven strangers stop being polite and start getting naked."
In addition to Marcus, Chemistry stars Dana DeArmond, Marie Luv, Mika Tan, Taryn Thomas, Jack Lawrence, and Kurt Lockwood.